THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES
نویسندگان
چکیده
منابع مشابه
The Biological Activity of Soluble Antigen-antibody Complexes
Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic. Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag(2)Ab), doe...
متن کاملT H E Biological Activity of Soluble Antigen-antibody Complexes Ii. Physical Properties of Soluble Complexes Having Skin-irritating Actmt¥*
Previous work by Germuth and McKinnon (1), Trapani et al. (2), and ourselves (3) has established the fact that soluble antigen-antibody complexes formed in excess antigen can, (a) induce symptoms similar to anaphylaxis, (b) cause contraction of isolated smooth muscle from normal guinea pigs, and (c) increase the permeability of skin capillaries in a manner similar to that obtained in passive cu...
متن کاملSoluble complexes of antigen and antibody fragments.
The insolubility of antigen-antibody aggregates formed at most proportions of reactants has prevented physicochemical study of these systems of interacting proteins under conditions in which they remain associated. Only when the antigen is present in great excess and soluble complexes are formed have the products been examined by ultracentrifugation (14)) moving boundary electrophoresis (l-3), ...
متن کاملThe Pathologic Effects of Intravenously Administered Soluble Antigen-antibody Complexes
The intravenous administration to mice of soluble antigen-antibody complexes in antigen excess resulted in a high incidence of glomerulonephritis and less frequently in endocarditis or arteritis. These lesions are present within 48 hours of the first of 3 injections and disappear within 2 weeks. The same pathological changes were produced with complexes prepared from either rabbit or chicken an...
متن کاملThe Cutaneous Reaction to Soluble Antigen-antibody Complexes
The in vivo activity of soluble antigen-antibody complexes was tested by a single intradermal injection in rabbits. Skin reactions were obtained marked by erythema, induration, and occasionally hemorrhage and necrosis. Microscopically, diffuse inflammation and occasional vascular necrosis could be found at all dosages. This indicates that soluble antigen-antibody complexes are phlogogenic and p...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1959
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.109.2.127